Cystic Fibrosis Foundation: Biological Basis for CF-Related Diabetes Program

Aim: better understand the biological underpinnings of CFRD, we are soliciting applications for basic research projects on the topic. Topics of include, but are not limited to the following:

Exocrine/endocrine interactions including: Absent/altered acinar cell signaling,

Incretins and enteroinsular axis, Impact of exocrine pancreatic disease on endocrine pancreas.

Altered/remodeled innervation and vasculature that impact islet function

Relationships between islet cells, inflammation, vasculature, macrophages, adipose tissue and development of CFRD.

Cellular pathways for islet maintenance.

Redox imbalance and inflammatory states that contribute to CFRD development and progression

CFTR-modulator reversible and non-reversible disease components :Prevention, delayed development, halting progression, disease reversal, Knowledge and gaps regarding CFTR modulator impact on pancreatic disease across the lifespan, Impact of early modulator use on pancreatic function, Relative CFTR modulation across CFTR-expressing tissues that may contribute to CFRD

Genes and pathways contributing to CFRD pathophysiology/pathogenesis including: Genetic modifiers and tissues of expression, Potential to impact genetic modifier targets.

Funding: up to $150,000/ year for up to 3 years.

https://www.cff.org/researchers/biological-basis-cf-related-diabetes-program