CDMRP: Amyotrophic Lateral Sclerosis Research Program (ALS) - Pre-proposals

• Pilot Clinical Trial Award: Supports exploratory clinical trials of novel therapeutics to demonstrate feasibility and inform the design of more advanced trials in ALS. Up to $2.M for 3 years.
• Clinical Biomarker Development Award:  Supports maximization of clinical ALS resources and biorepositories to better define subtypes, predict therapeutic response, or assess prognosis. Emphasis is on the development of clinical biomarkers to enrich clinical trials in ALS. Biomarkers may measure target engagement, pharmacodynamic effects, and/or be predictive/cohort-selective. Up to $500K for 2 years.
• Therapeutic Development Award:  Supports secondary preclinical validation and Investigational New Drug (IND)-enabling studies of therapeutics for ALS. Up to $1M for 3 years
• Therapeutic Idea Award: Supports hypothesis-driven preclinical therapeutic development. Up to $600K for 2 years

https://ebrap.org/eBRAP/public/ProgramFY.htm?programFYId=419101

https://ebrap.org/eBRAP/public/ViewFileTemplate.htm?fileTemplateId=10305295&fileType=pdf