National Institutes of Health (NIH): R21 Exploratory/Developmental Research Grants

Supports High-risk, high-reward studies that may lead to a breakthrough in a particular area, or result in novel techniques, agents, methodologies, models or applications that will impact biomedical, behavioural or clinical research. Funding: $275,000 for 2 years.

https://grants.nih.gov/grants/how-to-apply-application-guide.html#inst