DARPA: Make-It

DARPA: Make-It has the below topics of interest:

Make-It platforms will need to include the following features:

· Knowledge-based computational tools that derive potential synthetic design routes from a molecular structure;

· Algorithms that convert the synthetic design routes into a process flow optimized for the system components;

· Control algorithms that automate system components and can execute the instructions from the process-flow algorithm;

· Feed-forward/feed-back loops between the synthesis design tool, the control system and output characterization can optimize pathway selection; approaches that leverage real time data (i.e., learn from and improve the platform’s synthetic output) are highly desired; and

· Continuous flow modules for synthesis, in-line characterization, purification and formulation;

o The modules are an interconnected fluidic system that is fully automated via control algorithms;

o Module design and fluidic handling between modules enable a reconfigurable, generalizable platform;

o The fluidic handling is not complexity limiting;

o The analytical characterization and purification protocols are fully integrated with the synthesis modules;

o The final purification module should yield output that conforms to regulatory requirements such as Good Manufacturing Practice (GMP); and

o Monitoring/characterization is in-line, real-time and capable of determining the identity of both knowns and unknowns.

https://www.fbo.gov/index?s=opportunity&mode=form&id=5f57158a765fa716387d8e7ca432bd06&tab=core&_cview=0