DOD-CDMRP: DMRPD – Military Infectious Diseases Applied Research Award - Pre-application

This award seeks applied research applications focused on the reduction of combat-related or trauma-induced wound infection morbidity and mortality. Applications must address one of the following focus areas:

-Development of new methods for rapid multi-pathogen/multi-phenotype detection of multidrug-resistant organisms (MDRO's), nosocomial pathogens, and/or rapid multi-pathogen/multi-phenotype characterization of antimicrobial resistance patterns.

-Development of assays for host immune response biomarkers for diagnosis or prognosis (with associated outcomes) of infection to inform clinical wound management decisions (e.g. optimal wound closure time, optimal duration of antibiotics for osteomyelitis).

-Development and preclinical testing of novel chemotypes (chemical classes/materials), biologics as potential therapeutics or prophylactics for wound infection, and /or biofilm formation, maintenance, or propogation. Innovative treatment approaches (e.g. chelators, antibody, phage, antimicrobial peptides, quorum-sensing inhibitors, and host immunoaugmentation, etc.) are encouraged.

Funding: up to $2M over a maximum of 3 years. Approximately 5 applications will be awarded.

There is a Partnering PI Option under this mechanism is structured to accommodate up to three PIs who will each receive a separate award. One partner is identified as the Initiating PI and the other partner(s) as the Partnering PI(s). All investigators should collaborate in the development and submission of the proposed research project. Multidisciplinary and

multi-organizational projects are allowed.

https://cdmrp.org/Program_Announcements_and_Forms/