ALS Association: Phase II Clinical Trials in ALS - Letter of Intent

The ALS Association and the Massachusetts General Hospital Neurological Clinical Research Institute (NCRI) announce a call for Phase II clinical trial applications for novel, high potential treatments for ALS. There is an urgent need for improved ALS therapies as there is currently only one FDA-approved treatment for the disease, riluzole (Rilutek®). This Request for Proposals (RFP) aims to expedite the development of new therapies to test in people with ALS. The funders encourage academic-industry partnerships, including those involving pharmaceutical, biotherapeutic, biotechnology companies, academic members of the Northeast ALS Consortium (NEALS), and ALS scientists throughout the world, to submit clinical study proposals. Potential Phase II clinical trials should include interventions that have a pharmacodynamics marker that can measure whether pathway of interest has been affected and a plan to collect samples for biomarker studies. Clinical research support totaling $800,000 is available.

http://www.alsa.org/news/archive/rfp-mgh-alsa-protein-trial.html