Immune Tolerance Network (ITN): Clinical Trials of Immune Tolerance in Combined Bone Marrow and Solid Organ Transplantation

The ITN is currently seeking short “Concept Proposals” for novel clinical trials designed to induce immune tolerance in combined solid organ plus hematopoietic stem cell transplantation. The proposal should meet the following criteria:
1. Combine allogeneic solid organ transplantation (e.g., kidney or liver) with therapeutic cell transfer (e.g., bone marrow or hematopoietic stem cells) to induce donor-specific chimerism in the recipient without GVHD;
2. Cross HLA barriers between donor and recipient;
3. Utilize tolerance to the solid organ graft (full withdrawal of all immunosuppressive drugs without histologic or clinical evidence of rejection) as a clinical endpoint.
Phase II trials are of particular interest.