US Department of Health & Human Services/Office of Biomedical Advanced Research and Development Authority (BARDA): Division of Research, Innovation & Ventures (DRIVe)- (Abstracts)

(Abstracts may be submitted at any time until the closing date)

AOI #19 Healing Lungs

Address gaps in ARDS treatment by developing innovative technologies that enable oxygen delivery and gas exchange for severe ARDS patients, prevent secondary lung injury, and do not resort to mechanical ventilation or positive air pressure systems.

DRIVe is interested in the following two focus areas, which cover oxygen carrier injectable products and VV-ECMO:

1. Alternative methods for oxygen delivery and/or carbon dioxide removal
2. VV-ECMO:

* Maintaining balance between pro- and anticoagulant states in ECMO patients

* Approaches that make ECMO more compact and portable, easier to implement and operate

Funding: up to $750K.

https://drive.hhs.gov/partner.html

https://drive.hhs.gov/healinglungs.html

AOI #23 Host-Based Diagnostics

This program will bolster national preparedness by supporting the development, validation, and regulatory approval of host-based tools and approaches, with an emphasis on assessment of the clinical utility. HBDs encompass a broad range of technologies capable of leveraging various data types from an individual such as genomic biomarkers, cellular responses and physiological data, which may be analyzed by integrated algorithms.

Our current areas of focus include:

• Pathogen agnostic detection of infection, severity, or health deterioration in clinical settings outside of the hospital
• Demonstrate the clinical utility of HBDs for changing patient outcomes
• Utilize methods (e.g., cell-mediated immunity, epigenetic markers) that can inform on a patient's prior infectious status or current status of immunity
• Stratification of patient subpopulations to guide clinical trial design or identify appropriate treatment

Funding: up to $750K.

https://drive.hhs.gov/host-dx.html

https://drive.hhs.gov/partner.html